YouTube Preview: VKS ePanel on Intracellular Aggregates, Matthew Gentry, PhD

Date: May 15, 2019
Time: 2:00PM - 3:30PM EST
Link: http://bit.ly/VKSintracellular
Event Hashtag: #VKSintracellular

VKS ePanel: Intracellular Aggregates: Across the Spectrum of Health and Disease

Studies of aggregation-based disorders are typically associated with age-related pathology and primarily focused on extra-cellular buildup. However, intracellular aggregates or pre-oligomers may have unique disease-causing features that can be relatively overshadowed. The cytosolic presence of misfolded proteins or insoluble polyglucosan species are novel aspects of many genetic conditions as well as degenerative disorders. Therefore, this thought-provoking e-panel broadcast is designed to raise awareness, highlight new research findings, and search for commonalities among different intracellular aggregate species; including, novel treatment approaches to address aggregate-related diseases.

Topics covered include:

1. Comparing/contrasting a small variety of intracellular aggregates (e.g., desmin, APP, TDP-43, synucleins, polyglucosan bodies);

2. Identifying tissues, cell types, and/or subcellular compartments where the underlying protein or carbohydrate of interest can be found normally and/or in the disease state;

3. Discussing the normal role for the underlying protein or carbohydrate, and how it may aggregate in normal regenerative tissue or in diseased tissue;

4. Contextualizing these aggregates in terms of their disease relevance;

5. Determining commonalities, for instance among various intracellular aggregate clearance mechanisms;

6. Highlighting theoretical and ongoing translational studies for potential patient impact.

Following the panel discussion broadcast, audience members watching the live event will be able to participate in a live Q&A with the panelists. Questions can be submitted during the broadcast via Twitter or the chat room, or in advance when registering for the event.


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About Keystone Symposia:
Keystone Symposia is a 501(c)(3) nonprofit organization founded in 1972 that convenes 50-60 open, international scientific research conferences each year across the full range of the life sciences – from cardiovascular disease to immunology to neurobiology. The conferences accelerate life science discovery by bringing together and fostering collaboration among the world’s leading and next generation of research scientists.



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