Скачать или смотреть Route of 41BB/41BBL costimulation determines effector function of B7-H3-CAR.CD28ζ T cells

Presented By: Christopher DeRenzo, MD

Speaker Biography: Dr. DeRenzo is a pediatric oncologist and joined the Department of Bone Marrow Transplantation and Cellular Therapy at St. Jude Children's Research Hospital, where his goal is to develop and translate promising cell therapies from the laboratory into clinical trials for pediatric patients with solid tumors and brain tumors.

Webinar: Route of 41BB/41BBL costimulation determines effector function of B7-H3-CAR.CD28ζ T cells

Webinar Abstract: B7-H3 is actively being explored as an immunotherapy target for pediatric patients with solid tumors using monoclonal antibodies or T cells expressing chimeric antigen receptors (CARs). B7-H3-CARs containing a 41BB costimulatory domain are currently favored by several groups based on preclinical studies. Here we initially performed a detailed analysis of T cells expressing B7-H3-CARs with different hinge/transmembrane (CD8α vs CD28) and CD28 or 41BB costimulatory domains (CD8α/CD28, CD8α/41BB, CD28/CD28, CD28/41BB).

C.E. Credits: https://www.labroots.com/ms/virtual-e...