Скачать или смотреть Enabling more precise and individualized cancer treatment through biomarkers

Sabrina Ronen, professor in the Department of Radiology Biomedical Imaging at UCSF, is focused on developing new, non-invasive imaging biomarker indicators that characterize tumors. Ronen and her team are developing bio-markers that enable them to confirm delivery of a drug to the tumor. Once the oncologist has this information s/he can determine how to treat the patient in a much more precise and personalized way, targeting the treatment to the individual tumor. In this manner, the Ronen lab addresses breast cancer, prostate cancer and the higher-grade aggressive glioblastoma brain tumors as well as lower-grade, somewhat less aggressive brain tumors. They are pushing the envelope to work toward improving patient outcomes. There is a persistent challenge of resources and funding for students and postdocs, as well as equipment in the lab. The team focuses on the science and on delivering the very best possible imaging to the patient in-trial and in-clinic. The translation of research to the clinic provides us the ultimate achievement of our goals.





Profile: Sabrina M. Ronen, PhD, is a Professor in Residence in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Ronen completed her BS in Chemistry and Biochemistry at the Hebrew University in Jerusalem, Israel, received her MS in Chemistry from San Jose State University, and obtained her PhD in Chemical Physics from The Weizmann Institute of Science in Rehovot, Israel. She then trained as a postdoctoral fellow at the Institut Curie in Paris, France, and started her academic career at the Institute of Cancer Research in London, England.

Dr. Ronen’s Laboratory focuses on developing and mechanistically validating robust non-invasive translatable magnetic resonance (MR)–based biomarkers that can be used to monitor oncogenic transformation and response to therapy. Dr. Ronen has ongoing research projects on monitoring PI3K signaling, detecting the mutational status of isocitrate dehydrogenase, probing the metabolism of brain tumors, and determining the metabolomic profile of pancreatic cancer.

Expertise:
Magnetic resonance spectroscopy (MRS), spectroscopic imaging (MRSI), imaging (MRI), metabolism, cancer, bioengineering

Specialty:
Preclinical cancer models

Professional Interests:
Magnetic resonance, spectroscopy, imaging, cancer, metabolism, cell signaling, biomarkers

Education and Training:
• Bachelor of Science: Hebrew University, Jerusalem, Israel - Cum Laude, Chemistry and Biochemistry
• Masters of Science: San Jose State University, San Jose - Chemistry
• Doctor of Philosophy: Weizmann Institute of Science, Rehovot, Israel - Chemical Physics
• Postdoctoral Fellowship: Institut Curie, Paris, France - Imaging
• Postdoctoral Fellowship: Harefield Hospital, London, England - Imaging