Grounded: Infused Infected Broodmother solo [NG+4 Whoa! difficulty - No damage] (Lil Fist Edition)

Official Release v1.4.2.4535

Imagine having a faster attack speed than the Infected Broodmother.

Her Infusions:
Increased Movement Speed
Increased Attack
Increased Max Health
Projectile Bomb
Fresh Magic Attack
Explosive Attack
Damage Resist

Fury is working correctly in this patch, and +Unarmed Attack allows Lil Fist to compete with other weapons once it has max stacks. In addition, as long as one doesn't change weapons, Fury can also be chained with other trinkets to increase the player's stats further, such as myself reaching 110% attack speed here. Unfortunately, many skills that should work when combined with Fury have no effect, but they might in a future patch. If one didn't know, specific weapon buffs will stick around even if trinkets are switched mid-fight, and Fury allows for many otherwise unavailable combinations.

As for this fight, while it is possible, I don't recommend doing this solely on the phase change for the final phase alone due to the very high risk of getting hit by magic/bomb infusions when IBM fakes dying. One can manage to stun her to skip this danger during the first phase change due to fists having decent stun + Crit Stun from the Assassin's pieces, but the third phase shift killed more than the third phase itself (one will see me hesitate much during the last part of the second phase solely for this reason).

Not worth it, honestly. (Lil Fist is, though!)

As for the general strategy, one should start with a Science Cone/Glowbasa Necklace that has at least Fury + Samurai, then switch to one that has at minimum +Unarmed Damage so that IBM gets stunned when she has around half of her health remaining. To increase the chances of ending phase one successfully, temporarily unequip the shield to gain an extra 20% damage and re-equip it when the second phase starts. When safe from her infusion effects, switch to a trinket with Fury + Mad Scientist to build additional buffs, then switch back to the damage trinket once near the end of the phase. Depending on whether you want to use the Smasher mutation or Termite armor to reduce her heightened attack speed in the third phase will determine if you wish to pair another trinket with Fury and +Unarmed Damage or want to use a +Unarmed Damage trinket with additional modifiers such as +Boss Damage.

It took me almost a week to farm the trinkets needed for this fight.
Once again, I don't recommend this.

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Items and Equipment:
Strong Hand - And what a strong hand it is, thanks to Fury.

Ladybird Shield - There is a 25% chance that blocking with this shield will apply the stamina buff that allows the player to use no stamina while attacking for 5 seconds.

Glowbasa Necklace #1 - Fury / +Mantis Damage / Samurai

*Fury - Has the same effect as the Power Droplet, of which it adds an additional hit to unarmed attacks that do 6 damage and have a 25% chance to trigger specific mutation, armor, and trinket effects

*+Mantis Damage - Increases damage against the Mantis by 30% (Not useful here)

*Samurai - Every hit with katana-type weapons increases attack speed by 10%. This can stack up to 5 times. Although fists aren't katana-type weapons, thanks to Fury, the game considers them as such

Glowbasa Necklace #2 - Mad Scientist / Fury / +Summon Aggro

*Mad Scientist - Using the Pinch Whacker or Prod Smacker can increase attack damage or speed by 10%, exhaustion time by -10%, or increase crit chance by 1%. This only happens every 10% of hits. This also triggers Fury's effect

*Fury - (see above)

*+Summon Aggro - Increases the aggro chances for a summon to get attacked by the target (Not useful here)

Glowbasa Necklace #3 - +Critical Hit Chance / +Boss Damage / +Unarmed Attack

*+Critical Hit Chance - Increases crit chance by 5%

*+Boss Damage - Increases damage against bosses by 30%

*+Unarmed Attack - Increases fist damage by 100%, which is quite good once Lil Fist stacks are maxed out

Eyepatch Lv. 0 - Adds 10% more to one's attack but at the cost of taking 25% extra damage.

Assassin's Chestplate Lv. 9 (Sleek) - Critical hits have a 30% chance of causing a bleed debuff. Since the Infected Broodmother is 60% resistant to bleed, this ends up doing 8 damage a second for 10 seconds. In addition, each crit has a 30% chance to add 25 stun to IBM, thanks to Crit Stun.

Assassin's Greaves Lv. 9 (Sleek) - Same as the above.

Termite Armor Lv. 9 (Sleek) - This armor piece has a 10% chance to kick up dust upon hitting the enemy. While inside the cloud, the enemy's attack and movement speed are lowered by -20% until the effect ends. It also grants you immunity to the same dust cloud.

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Food and Drinks: (due to the cooldown for using buffs, I skipped recording these actions)
Perfect Toast - +5% crit chance and +40% to critical hit damage
Boss Sauce - +5% crit chance
Liquid Rage - +10% attack
Green Machine - 20% faster stamina recovery
Boost Juice - +20 stamina

(I will continue this description in a pinned comment)