Mastering Loop diuretics: The key to effective diuresis!

A quick guide on achieving effective diuresis in inpatient settings will discuss loop diuretics, their mechanism of action, and a side-by-side comparison of furosemide, torsemide, and bumetanide. We will also discuss acute loop diuretic tolerance (post-diuretic sodium retention) and chronic tolerance and how to overcome both, Bolus vs continuous infusion of loop diuretics. When to use fluid restriction, the importance of a low sodium diet, signs of over-diuresis, the use of albumin, monitoring patients while on loop diuretics, how to titrate up the dose of loop diuretics, the use of loop diuretics in liver cirrhosis, diuresis in patients with volume overload and metabolic alkalosis and the role of acetazolamide, and how to tackle refractory edema and the role of metolazone.


00:14 The definition of diuresis.
00:25 Site of loop diuretic action.
00:57 Loop diuretics (Furosemide, Torsemide, Bumetanide, Ethacrynic acid).
01:36 Loop diuretics mechanism of action
02:33 Side-by-side comparison between Furosemide-Torsemide-Bumetanide
03:22 Loop diuretics dose conversion
04:57 Loop diuretic bolus therapy and acute tolerance
06:12 Loop diuretics drip/ continuous infusion
07:00 Threshold dose and maximum effective dose concept of loop diuretics.
07:53 Threshold dose and maximum effective doses of individual loop diuretics (Furosemide, Torsemide, Bumetanide) in Heart failure, Cirrhosis, Nephrotic syndrome, and acute/chronic kidney diseases.
07:53
09:46 Tolerance to loop diuretics and how to overcome that
11:32 Ototoxicity and the relation to total maximum daily loop diuretic dose.
11:56 Measures used in all patients with volume overload.
12:12 Fluid restriction in volume overload, when and how.
12:48 Monitoring patients while on loop diuretics
13:22 Signs of overdiuresis
13:46 The use of albumin in diuresis
14:36 How to titrate up loop diuretics
15:03 The use of Loop diuretics in liver cirrhosis patients
15:41 Metabolic alkalosis and fluid overload, the role of acetazolamide.
16:02 Refractory edema and the role of using metolazone


Sign up for video summaries on substack using this lA quick guide on achieving effective diuresis in inpatient settings will discuss loop diuretics, their mechanism of action, and a side-by-side comparison of furosemide, torsemide, and bumetanide. We will also discuss acute loop diuretic tolerance (post-diuretic sodium retention) and chronic tolerance and how to overcome both, Bolus vs continuous infusion of loop diuretics. When to use fluid restriction, the importance of a low sodium diet, signs of over-diuresis, the use of albumin, monitoring patients while on loop diuretics, how to titrate up the dose of loop diuretics, the use of loop diuretics in liver cirrhosis, diuresis in patients with volume overload and metabolic alkalosis and the role of acetazolamide, and how to tackle refractory edema and the role of metolzone.


00:14 The definition of diuresis.
00:25 Site of loop diuretic action.
00:57 Loop diuretics (Furosemide, Torsemide, Bumetanide, Ethacrynic acid).
01:36 Loop diuretics mechanism of action
02:33 Side-by-side comparison between Furosemide-Torsemide-Bumetanide
03:22 Loop diuretics dose conversion
04:57 Loop diuretic bolus therapy and acute tolerance
06:12 Loop diuretics drip/ continuous infusion
07:00 Threshold dose and maximum effective dose concept of loop diuretics.
07:53 Threshold dose and maximum effective doses of individual loop diuretics (Furosemide, Torsemide, Bumetanide) in Heart failure, Cirrhosis, Nephrotic syndrome, and acute/chronic kidney diseases.
07:53
09:46 Tolerance to loop diuretics and how to overcome that
11:32 Ototoxicity and the relation to total maximum daily loop diuretic dose.
11:56 Measures used in all patients with volume overload.
12:12 Fluid restriction in volume overload, when and how.
12:48 Monitoring patients while on loop diuretics
13:22 Signs of overdiuresis
13:46 The use of albumin in diuresis
14:36 How to titrate up loop diuretics
15:03 The use of Loop diuretics in liver cirrhosis patients
15:41 Metabolic alkalosis and fluid overload, the role of acetazolamide.
16:02 Refractory edema and the role of using metolazone


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