DNA, Fantastic! Mr. W's DNA Rap

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SUMMARY: This video provides a musical explanation of DNA, its structure, and its role in biological life. DNA, or deoxyribonucleic acid, is the essential molecule that carries genetic information in all living organisms, controlling development and heredity. The double helix structure, composed of sugar-phosphate backbones with nitrogenous bases (A, T, C, G) forming rungs, is key to its function. Complementary base pairing (A with T, C with G) is explained, along with the contributions of scientists Watson, Crick, and Franklin in discovering DNA’s structure. The song also explains how small mutations in DNA can lead to significant changes, resulting in genetic conditions such as sickle cell anemia.

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LYRICS:

Welcome, I'm so happy you came by
For a lesson 'bout the essence of b-i-o-l-o-g-y
DNA's the topic, it's so fantastic,
We talking 'bout Deoxyribonucleic acid

If you've ever wondered 'bout development in elephants
or bumble bees, coffee trees, well DNA's the recipe
In its home in a chromosome in the nucleus
DNA drives the bus, genetically controlling us

In ferns and worms infectious germs, mommy's egg and daddy's sperm
DNA's the information linking up the generations
It's the code of life so listen up well,
'Cause DNA's the molecule in charge of every cell

CHORUS
DNA! Fantastic
Deoxyribonucleic Acid
We talking 'bout Deoxyribonucleic acid.
DNA! Fantastic

The shape is key and probably well known to you
Double helix, twisted ladder, or a double corkscrew
Imagine a twisted length of tape with
deoxyribose sugars on the edges with phosphates

Sugar phosphate sugar phosphate making up the sides of the
ladder with nitrogenous bases on the inside
with the bases like the rungs and together with
deoxyribose sugar and a phosphate make a nucleotide

Deoxyribonucleotides are the monomers
link them up together for the DNA polymer
Point three four nanometers marks the space between
one nucleotide and the next one's place

And for the helix to make one turn takes
10 bases in a row as you can discern
Since space 'tween nucleotides is point three four, one
turn takes nanometers three point four

So stylish!, So slick!
first described in fifty three by Watson and Crick and
don't forget Franklin she took that famous X-Ray pic
but she died so she never got her Nobel prize.

CHORUS
DNA! Fantastic
Deoxyribonucleic Acid
We talking 'bout Deoxyribonucleic acid.
DNA! Fantastic

The nitrogenous bases comes in one of four varieties,
Known by the letters A, T, C and G
A is for Adenine, Thymine's got the "T"
C it stands for Cytosine and Guanine's got the "G"

A and G with two nitrogen rings are purines
C and T with one ring are pyrimidines
C only bonds with G, A only with T
Because like puzzle pieces they're complementary

They fit together. snuggled up like hand and glove,
like enzymes and substrates, like people in love
A-T, C-G, matched up like lock and key
Forming hydrogen bonds, either two or three.

Hydrogen bonds, you know they aren't very strong,
But they're enough to hold DNA together all day long
The way the bases fit together couldn't be sweeter,
they give DNA a width of two nanometers

DNA's double stranded, looks pretty swell
The strands' orientation is anti parallel
With one standing up, the other on its head
It's how they fit together, Crick and Watson said!

CHORUS

Sugars and phosphates make the backbone, the structure
But the sequence of the bases is where you find instructions for
Development of bodies and the cytoplasmic symphony,
That constitutes life's miracle in goats and golden algae,


FOR COMPLETE LYRICS, download the sciencemusicvideos songbook at https://apbiosuccess.com/songbook.