How do osteoclasts resorb bone?

Osteoclasts are large multinucleated giant cells having around 15-20 nuclei, whose function is to resorb bone. They play a very important role in bone remodeling and are characterized by the presence of an enzyme called tartrate resistant acid phosphatase (TRAP).

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References and further reading:
💡Feng X, Teitelbaum SL. Osteoclasts: New Insights. Bone Res. 2013;1(1):11-26.
💡Hienz SA, Paliwal S, Ivanovski S. Mechanisms of Bone Resorption in Periodontitis. J Immunol Res.2015;2015:615486.
💡Nanci A. Tencate’s Oral Histology. Development, Structure and Function. 8th ed. Elsevier;2013.
💡Kumar GS. Orban’s Oral Histology and Embryology.13th ed. Elsevier;2011.

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