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INSIGHT 2023 Replay from the Clinical Researcj Track:

Talk – Dosing Psychedelics: What the Research Tells Us
Prof. Dr. med. Matthias Liechti (University Hospital of Basel)

Finding the right dose is one of the most critical factors in the safe and effective use of psychedelic substances. In this talk, Prof. Dr. Matthias Liechti presents key findings from a series of controlled studies conducted at the University Hospital of Basel on the acute dose-dependent effects of MDMA, psilocybin, LSD, mescaline, and DMT in healthy participants.

The session offers evidence-based recommendations for optimal dosing strategies, including how to adjust for sex, weight, and other individual factors. Dr. Liechti also discusses important drug-drug interactions that may impact psychedelic therapy, particularly in combination with established treatments like antidepressants—an increasingly relevant concern in clinical settings.