Скачать или смотреть Exploring the Role of PD 1 in Gamma Delta T Cells and Autoimmune Disease

🔬 PD-1, γδ T Cells & Autoimmunity: A Deep Dive into CNS Inflammation 🔬
In this video, we break down the 2024 European Journal of Immunology paper titled "PD‑1 regulation of pathogenic IL‑17‑secreting γδ T cells in experimental autoimmune encephalomyelitis" by Leane et al.

Assay Genie Antibodies used:

https://www.assaygenie.com/anti-mouse...

https://www.assaygenie.com/rat-igg2a-...

💥 What’s inside?
We explore how the immune checkpoint receptor PD‑1 regulates IL‑17A‑producing γδ T cells—and how blocking PD‑1 dramatically worsens disease in a mouse model of multiple sclerosis (EAE).

📊 We walk through the key figures:

Figure 1: PD‑1 expression surges on pathogenic Vγ4 γδ T cells

Figure 2 & 3: Anti‑PD‑1 enhances IL‑17A production and CNS infiltration

Figure 4: Disease worsening is γδ T‑cell–dependent

Figure 5: PD‑1 regulates TCR-induced, but not cytokine-induced, IL‑17 production

🧠 Why it matters:
This study reveals a previously underappreciated role for PD‑1 in restraining pathogenic γδ T cell responses, with direct implications for autoimmune disease progression and cancer immunotherapy.

📚 Original paper:
Leane CM et al. (2024). Eur J Immunol. DOI: 10.1002/eji.202451212

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