Lymphoma: Overview of Chimeric Antigen Receptor (CAR) T cells

This Harvard Medical School Continuing Education video examines these key questions: what are CAR T cells, in what diseases are they utilized, and what are the common toxicities of CAR T cells?

Dr. Connor Johnson, MD, an oncologist at Massachusetts General Hospital, discusses chimeric antigen receptor cell therapy (CAR T) with a particular focus on lymphoma. The logistics of CAR T-cell therapy are described and toxicities are identified, including cytokine release syndrome (CRS), ICANS, and cytopenias.

00:00 | Introduction
00:37 | Overview of CAR T cells and immunology principles
02:16 | CAR T cells therapies and targets
02:48 | Logistics of CAR T-cell therapy
03:43 | Toxicities related to CAR T-cell therapy

This video was peer reviewed by Dr. Jonathan Salik, TMD, MHPEd, Instructor of Medicine, Massachusetts General Hospital; and Dr. Sugantha Sundar, MD, Assistant Professor of Anesthesia, Beth Israel Deaconess Medical Center, to validate the quality and accuracy of the content. It was edited by affiliate physicians of Harvard Medical School, Arielle J Medford, MD, Senior Medical Oncology Fellow, Dana-Farber Cancer Institute and Anna Handorf, MD, Research Fellow in Pediatrics, Massachusetts General Hospital.

References:
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Notice: At this time, the content in this video is not accredited.