Molecular Profiling of Colorectal Cancer and Fibroblasts | Protocol Preview

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Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts - a 2 minute Preview of the Experimental Protocol

Marc D. Bullock, Max Mellone, Karen M. Pickard, Abdulkadir Emre Sayan, Richard Mitter, John N. Primrose, Graham K. Packham, Gareth Thomas, Alexander H. Mirnezami
University of Southampton School of Medicine, Cancer Sciences Unit; University of Southampton School of Medicine, University Surgical Unit; London Research Institute, Cancer Research UK, Bioinformatics Unit;

Molecular profiling of laser microdissected cells and stroma from synthetic, tissue-engineered colorectal cancer models represents a novel and manipulatable approach to characterize and dissect the distinctive biology at the interface between tumor cells at the invasive front and cancer associated stromal cells.  

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