Скачать или смотреть How Epigenetic Drift Accelerates Aging and Cancer in the Gut

New research from the Leibniz Institute on Aging and the University of Turin uncovers a key mechanism behind intestinal aging and cancer risk.
In this video, explore how 'epigenetic drift'—specifically ACCA drift—builds up in intestinal stem cells over time, shutting down vital genes through hypermethylation. Learn how factors like inflammation, weakened Wnt signaling, and iron metabolism loss drive this process, and why older intestines become more cancer-prone.
Discover how scientists managed to slow or even reverse these changes in lab-grown intestinal organoids by restoring iron balance and reactivating Wnt signaling—offering hope that molecular aging might one day be slowed or modified.
Keywords: epigenetic drift, intestinal stem cells, ACCA drift, gut aging, colon cancer, DNA methylation, Wnt signaling, iron metabolism, inflammation, Nature Aging research, Francesco Neri, Anna Krepelova.
Watch to understand how these molecular ‘switches’ in the gut could redefine what we know about aging and cancer prevention.