Скачать или смотреть Roxadustat: Beware of the side Effects of this New Anemia Pill | More Heart Attacks and Clots

Below is the refrence from uptodate.com:Roxadustat – The efficacy of roxadustat was examined in a phase 3 trial of over 2700 patients with nondialysis CKD and anemia (baseline mean Hb 9 g/dL) who were randomly assigned to receive roxadustat, or placebo thrice weekly, targeting an Hb of at least 11 g/dL [34]. Compared with those taking placebo, patients taking roxadustat were more likely to achieve the target Hb (77 versus 9 percent) and achieved an Hb in the range of 10 to 12 g/dL for a greater proportion of time (82 versus 28 percent). In addition, compared with placebo, roxadustat led to a 74 percent overall reduction in the need for other treatment of anemia (with iron, ESA, or transfusions) and 63 percent reduction in the need for transfusions alone. However, all-cause mortality (21 versus 18 percent), cardiovascular events (23 versus 21 percent), and overall serious adverse events (57 versus 54 percent) were higher among patients on roxadustat compared with patients on placebo. Serious adverse events that were more common with roxadustat included hypertension, urinary tract infections, and pneumonia. Similar findings have been reported in other smaller phase 3 trials from the European Union [35], China [36], Japan [37], and other countries [38]. The FDA declined approval of roxadustat in the United States due to these safety concer
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Professor Dr. Shafiq Cheema is a Gold Medalist and was the most distinguished Graduate of KEMU, in 1996. He has extensive training & experience in the field of Internal Medicine, Hypertension, and Nephrology. He is a Diplomat American Board of Internal Medicine and Nephrology as well as a Fellow of the American College of Physicians and American Society of Nephrology. He is a renowned Hypertension specialist by ASH. He was lately appointed as Professor of Nephrology at AIMC-Jinnah Hospital. He is amongst America’s top Nephrologists and the world's leading physician. He is the Founder & Patron in Chief of Pak Kidney Foundation (PKF), Chairperson MD Nephrology UHS, and Founder of NephChat with Dr. Shafiq Cheema, providing valuable awareness through YouTube videos related to different diseases. He has worked extensively in the USA in senior positions, including, as former Medical Director of FMC North America, USA, Former Assistant Professor UTHSC Texas, Former Chief of Medicine LMC Texas.