Phase I trial of MCARH109, a GPRC5D-directed CAR T-cell, for patients with R/R multiple myeloma

Eric Jurgens, MD, Memorial Sloan Kettering Cancer Center, New York, NY, shares updated results from a Phase I trial exploring the safety and efficacy of MCARH109, a GPRC5D-directed CAR T-cell therapy, for patients with relapsed/refractory (R/R) multiple myeloma. Overall, 12 out of 17 patients responded, with a median duration of response of 8.6 months and a three-year overall survival (OS) estimate of 59%. The study also reveals potential GPRC5D antigen escape, suggesting the need for alternative targeting strategies to enhance patient responses. This interview took place at the 21st International Myeloma Society (IMS) Annual Meeting, held in Rio de Janeiro, Brazil.

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