Скачать или смотреть Discover the molecule that could be the key to Anti-aging and Longevity.

In this episode, we have Dr. Dudley Lamming, PhD, Associate Professor and Researcher at the Department of Medicine, Endocrinology at the University of Wisconsin-Madison. We will talk about aging and specifically about a molecule that has been gaining interest in the scientific field: mTOR. We’ll discuss its importance, how it is regulated, and much more. Additionally, we will explore the effects of Rapamycin and its potential pharmacological applications. Join us for an insightful discussion! Dr. Lamming’s research focuses on understanding how nutrient-responsive signaling pathways can be harnessed to promote health and longevity.

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Reference: Mannick JB, Lamming DW. Targeting the biology of aging with mTOR inhibitors. Nat Aging. 2023 Jun;3(6):642-660. doi: 10.1038/s43587-023-00416-y. Epub 2023 May 4. PMID: 37142830; PMCID: PMC10330278.

Timestamps:
00:00 Introduction
01:12 Introduction to the topic
02:07 Motivation to investigate mTOR and aging
02:55 What is mTOR relevant for?
07:23 What activates mTOR under physiological conditions?
08:36 What happens after mTOR is activated?
09:42 Pharmacological inhibition and longevity
10:26 When does hyperactivation become a problem?
12:03 Rapamycin and its mechanism
21:29 What does mTOR do in protein translation?
23:40 What is the health benefit of continuing autophagy?
24:44 The effect on immunity
26:20 Making it of practical use in humans
30:32 Lifestyle changes that affect mTOR
34:30 What’s coming next in your research

Disclosure:
The content of this podcast is purely academic in nature and is intended for educational and informational purposes only. The material discussed does not represent or reflect the views, opinions, or policies of the Medical College of Georgia, and the information presented should not be construed as medical advice or guidance. Always consult with a qualified healthcare professional for any medical concerns or questions. I'd like to explicitly state that I have no endorsement from, affiliations with, or financial interests in any pharmaceutical companies or medical device manufacturers. Any mention of medications, devices, or treatments is made solely within the context of literature and academic discussion.