Скачать или смотреть Biotransformation of drugs -part 2 | phase 1 & 2 reactions | Pharmacokinatic

Biotransformation of drugs -part 2 | phase 1 & 2 reactions | Pharmacokinatic

Metabolism or biotransformation of drugs or medicines is a pharmacokinetic property of drugs which is the irreversible alteration in the chemical nature of a drug. These reactions may be anabolic and catabolic reactions involving mainly endogenous substances like hormones, steroids, etc. but most of the drugs are also undergo these types of reactions and some functional groups are attached or exposed by drug-metabolizing enzymes.
Pharmacology is the study of drugs. Pharmacology mainly subdivided into two main branches pharmacokinetic and pharmacodynamic. Pharmacokinetics is mainly concern with the kinetics of drugs inside the body or simply what the body does to a drug. In contrast, pharmacodynamics is concerned with the effects of drugs on the body or simply what the drug does to our body. So, metabolism is pharmacokinetic property through which various changes takes place in the structure of drug which is done to facilitate its excretion from the body through excretory organs. Drugs metabolic reactions are divided into phase 1 and phase 2 reactions. In phase 1 reactions a functional group is exposed or added to the drug structure while in phase 2 reactions an endogenous substance is covalently attached to the drug molecule.

Covered topics:
Drug Metabolic reactions
Phase 1 reactions
Oxidation
Hydroxylation
N-dealkylation
O-dealkylation
Deamination
N-oxidation
S-Oxidation
Desulfuration
dehydrogenations
reduction
hydrolysis

Phase 1 reactions
Glucuronide conjugation
Acetylation
Methylation
Sulfate conjugation
Glycine conjugation
Glutathione conjugation
GENERAL OVERVIEW

REFERENCES:
Goodman and Gilman
The Pharmacological Basis of Therapeutics
Eleventh Edition
Rang and Dale's Pharmacology, Seventh Edition- H. P. Rang
Katzung - Basic and Clinical Pharmacology
12th Edition
Lippincott Illustrated Reviews, Pharmacology - Whalen, Karen
Sixth edition
Netter's Illustrated Pharmacology, Updated Edition- Robert B. Raffa
Essentials of Medical Pharmacology(Jaypee) - K.D. Tripathi
Seventh edition
A Textbook of Clinical Pharmacology and Therapeutics
Fifth edition
By: JAMES M RITTER, LIONEL D LEWIS, TIMOTHY GK MANT, ALBERT FERRO
Netter's Illustrated Pharmacology, Updated Edition- Robert B. Raffa

Links:
Also watch:
drug biotransformaion part 01
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