Exploring Spatial Protein Interactions Mechanics: A Beginner Guide |

Have you ever wondered why proteins are essential to biomaterials engineering? In this video, we'll explore the fascinating and complex world of protein interactions and explain Spatial Protein Interactions Mechanics. From composition, affinity, and lifetime to focal adhesions, integrins, and the cytoskeleton, we'll uncover the intricate details of how proteins interact with each other and with biomaterials. Get ready to unlock the secrets of protein interactions!

In this video, Dr. Loay Al-Zube, an associate professor of biomedical engineering, explains how cell Proteins Interact with other proteins and with Biomaterials, and explains Spatial and Mechanical Information (Biomaterials Engineering). Protein-protein and protein-material interactions play important roles in various biological processes. Protein interactions can be classified based on different factors, including composition, affinity, and lifetime.
Protein fibers and extracellular space constitute the extracellular matrix (ECM). Cells attach to the ECM via focal adhesions. This transmits information about the spatial mechanical environment to the interior of the cell by the integrin-protein-cytoskeleton connectivity.

In this video, you will learn that Integrins integrate the ECM (fibronectin) and the cytoskeleton (actin microfilament). Regulation is possible from both directions: binding of fibronectin to integrins allows the action of FAK; but phosphorylation (probably - the details are still sketchy) of the integrin from within causes it to dissociate from cytoskeleton-binding proteins such as talin. It seems likely that this also causes conformational changes in the extracellular portion of the integrin, loosening its grip on the ECM. Clusters of integrins with other proteins form what are known as focal adhesions.

Cells sense the spatial-mechanical of their external environment by attachment via focal adhesions. The spatial and mechanical information is transmitted throughout the cell by the response of the tensegrity architecture of the cytoskeleton. The response of the cytoskeleton initiates a protein signaling process.

This lecture explains protein protein and protein material interaction in cells during cell division and muscle contraction. Protein–protein interactions (PPIs) confer with intentional bodily contacts headquartered between two or extra proteins as a result of biochemical hobbies and/or electrostatic forces. #BME210

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Dr. Loay Al-Zube
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How Do Proteins Interact with Other Proteins and with Biomaterials? | Biomaterials Engineering
Biomaterials: Protein Interaction with Biomaterials (Video 10): Spatial and Mechanical Information

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