Скачать или смотреть Targeting Rogue DNA for Cancer Treatment | Future Technology & Science News 516

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TRANSCRIPT

A recent breakthrough has uncovered that aggressive, treatment-resistant #cancers may be driven by extrachromosomal DNA (ecDNA), rogue fragments that separate from chromosomes and reside independently in the cell nucleus.

These #ecDNA fragments carry cancer-promoting genes and suppress immune responses, contributing to chaotic replication and aggressive tumor growth. Promisingly, drugs called #CHK1 inhibitors, when combined with traditional cancer treatments, were shown to selectively target and destroy ecDNA-rich tumor cells in mice.

Researchers are hopeful this discovery could lead to new therapies, potentially transforming aggressive cancers into treatable conditions.

Source: https://www.nature.com/articles/s4158...

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