A Novel NAD+ Precursor Trigonelline More Stable Than NR & NMN | Dr Vincenzo Sorrentino Ep 1

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Here Dr Sorrentino introduces trigonelline a methylated form of nicotinic acid which can boost NAD levels. He also talks about his work at Singapore and the translation of longevity science into the clinic.
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⏲️Chapters
00:00 Introduction to Dr Sorrentino
01:50 Translation from lab to clinic
05:50 How to tailor interventions
08:00 Singapore longevity framework
11:30 Trigonelline
14:50 Trigonelline metabolism
18:30 cf. Nicotinic acid
19:30 Raising NAM

🌐Links in this video
Dr Sorrentino's page at NUS
https://medicine.nus.edu.sg/bch/facul...

Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulation by the ubiquitin-proteasome system. Subsequently, he moved to Lausanne, Switzerland, for his postdoctoral research in Prof. Johan Auwerx’s lab at the EPFL. His work there focused on the understanding of mitochondria and NAD+ metabolism in neurodegeneration and muscle aging. He then obtained a position as Group Leader at the Nestlé Institute of Health Sciences in Lausanne, to lead research focused on integrating basic discoveries on nutraceuticals and their effects on mitochondria and protein homeostasis with their translation into novel clinical applications. Since December 2022, he is an Assistant Professor at the NUS with the Dept. of Biochemistry and the Healthy Longevity TRP, Yong Loo Lin School of Medicine, to continue to develop his research on how metabolism, nutrition and proteostasis are linked and impact on health and aging.

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#NAD #trigonelline #nr