Clearance in first order and zero order kinetic

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Video Summary:
Clearance is volume of plasma completely cleared of drug. In first order kinetic, as concentration increases, the amount of drug eliminated also increases. As a result, volume of plasma cleared remains the same. Thus clearance remains constant. In zero order kinetic, amount of drug eliminated is fixed for all concentrations. So at lower concentrations more plasma is cleared and as concentration increases, less and less plasma is cleared. Thus clearance is not constant in zero order kinetic.

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DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorized websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.