Скачать или смотреть Role of Nav1.8 Channels Regulating Human DRG Neuron Excitability Using Suzetrigine | Dr. Bruce Bean

Nav1.8 Sodium Channels in Human DRG Neurons: Implications for Acute Pain Presented by Dr. Bruce Bean, Professor of Neurobiology, Harvard Medical School

In this installment of the AnaBios Translational Research Webinar Series, Dr. Bruce Bean explores the critical role of Nav1.8 voltage-gated sodium channels in regulating excitability in human dorsal root ganglion (DRG) neurons and their relevance to acute pain signaling.

Dr. Bean presents new preclinical findings on suzetrigine (Journavx), a selective Nav1.8 inhibitor, highlighting how state- and temperature-dependent channel inhibition alters neuronal firing at physiological temperatures. This data provides important mechanistic insight into why Nav1.8 represents a compelling and clinically relevant target for pain therapeutics.

This webinar is highly relevant for scientists working in:
• Pain biology and sensory neuroscience
• Ion channel pharmacology
• Drug discovery and translational research
• Human-relevant preclinical models

Key topics covered:
• Nav1.8 function in human DRG neuron excitability
• Temperature-dependent sodium channel pharmacology
• Mechanistic basis of acute pain signaling
• Translational implications for Nav1.8-targeted therapies

Speaker:
Dr. Bruce Bean
Professor of Neurobiology, Harvard Medical School

About the Series:
The AnaBios Translational Research Webinar Series features leading scientists discussing cutting-edge research that bridges human-relevant biology and drug discovery.

To learn more about AnaBios, visit www.anabios.com.

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