High Grade Serous Carcinoma of the Ovary - Histopathology

Описание к видео High Grade Serous Carcinoma of the Ovary - Histopathology

High-grade Serous Ovarian Adenocarcinoma
Most common ovarian carcinoma
Histology: branching papillae, cellular budding and tufting, detached cellular clusters
Patterns: papillary with slit-like spaces, solid, endometriod, transitional - SET appearance more commonly associated with BRCA1 mutations -, microcystic/microglandular
Nuclear pleomorphism, more than 3x variation in size
High mitotic index: more than 12 mitotic figures per 10 high power fields, often atypical
Necrosis
Immunohistochemistry: p53+, p16+, WT1+, PAX8+
The stage is the most important prognostic factor
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#gynpath #pathology

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