How does DNA methylation impact synaptic transmission?

Описание к видео How does DNA methylation impact synaptic transmission?

We found that synaptic transmission in inhibitory interneurons is modulated by DNA methylation-dependent regulation of endocytosis-related genes. As changes in neuronal activity can lead to alterations in DNA methylation profiles, this could serve as a subcellular mechanism for neuronal metaplasticity.

Analysis of human brain sample analysis further points to a potential implication of DNA methylation-dependent endocytosis regulation in the pathophysiology of temporal lobe epilepsy, a disease characterised by disturbed synaptic transmission.

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