Скачать или смотреть Carbon Monoxide Poisoning EXPLAINED: Pathophysiology, Diagnosis & Treatment | USMLE Review

Carbon monoxide (CO) poisoning is a critical topic for the USMLE exams. In this high-yield review, we delve into the pathophysiology, clinical presentation, diagnostic strategies, and treatment protocols essential for mastering this subject.

🔍 What You’ll Learn:
Pathophysiology: Understanding how CO binds to hemoglobin with an affinity ~210 times greater than oxygen, leading to tissue hypoxia.
Clinical Presentation: Recognizing symptoms such as headache, dizziness, nausea, and the classic "cherry-red" skin appearance.
Diagnosis: Utilizing CO-oximetry to detect elevated carboxyhemoglobin levels and understanding the limitations of pulse oximetry in CO poisoning cases.
Treatment: Administering 100% oxygen or hyperbaric oxygen therapy to displace CO from hemoglobin and restore oxygen

📌 Timestamps:
0:00 – Intro
0:30 – Difference between carbon monoxide poisoning vs cyanide poisoning
2:12 – Review of normal physiology
3:52 – Pathogenesis of CO poisoning
5:19 – The clinical significance of Left shift in oxygen dissociation curve
14:30 – Inhibition of complex 4 in Mitochondria
19:35 – Clinical symptoms and cherry red skin explained
20:36 – Pathogenesis of bilateral globus pallidi
22:06 – The components of tissue hypoxia (bound and dissolved oxygen changes)
23:06 – The logic behind the treatment

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