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An antisocial maverick doctor who specializes in diagnostic medicine does whatever it takes to solve puzzling cases that come his way using his crack team of doctors and his wits.

This long-running medical drama follows the professional and personal life of Gregory House- a witty, arrogant, rule-breaking, self-destructive, pain-pill addicted but genius diagnostician at the fictional Princeton-Plainsboro Teaching Hospital in New Jersey. House and his team of doctors work against the clock to diagnose and treat patients when other doctors can't seem to figure out what's wrong with them, often resorting to unorthodox methods based on House's hunches on the patients, their families, or his own personal experiences.