Enterotoxigenic Escherichia coli LT inhibits intestinal ascorbic acid uptake

Описание к видео Enterotoxigenic Escherichia coli LT inhibits intestinal ascorbic acid uptake

Ganapathy A. Subramenium, PhD, and Subrata Sabui, PhD, University of California-Irvine delivered the lecture on the effect of Enterotoxigenic Escherichia coli (ETEC) infection on intestinal ascorbic acid uptake. The team found that heat-labile enterotoxin (LT) produced by ETEC inhibits AA uptake in intestinal epithelial cells and mouse intestine. This effect is mediated through transcriptional repression of SLC23A1 (SVCT1) and SLC23A2 (SVCT2) via a cAMP-dependent NF-κB signaling pathway. (Full article: https://doi.org/10.1152/ajpgi.00259.2018)

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