Neste vídeo, vamos investigar a fundo a biologia e a química do vírus causador da Mpox (antiga varíola dos macacos) e entender por que a cepa de 2026 ligou o alerta máximo da OMS e dos infectologistas no Brasil logo após o Carnaval.
#mpox #mpoxvirus #ciencia
00:00 Introdução
02:34 Afinal, o que é o MPOX?
04:55 De onde surgiu o Vírus Mpox?
06:10 O primeiro caso em HUMANOS
09:45 APOBEC3 o Paradoxo
13:07 Tem Medicamento para Tratar?
14:35 ABOMBA da OMS (Vírus Híbrido)
17:00 Tem vacinas?
19:07 Como se Prevenir?
20:25 CALMA!
📚 Referências Utilizadas:
📄 Khan MI, Saleh AA, Ali R, Jan RU, Gu J, Dejun J. 2025. The evolving mpox threat (2022–2024): clade dynamics, immune evasion, and escalating global health challenges. Front Cell Infect Microbiol 15:1677762. https://doi.org/10.3389/fcimb.2025.16...
📄 Huang Y, Mu L, Wang W. 2022. Monkeypox: epidemiology, pathogenesis, treatment and prevention. Signal Transduct Target Ther 7:373. https://doi.org/10.1038/s41392-022-01...
📄 Reed KD, Melski JW, Graham MB, Regnery RL, Sotir MJ, Wegner MV, Kazmierczak JJ, Stratman EJ, Li Y, Fairley JA, Swain GR, Olson VA, Sargent EK, Kehl SC, Frace MA, Kline R, Foldy SL, Davis JP, Damon IK. 2004. The detection of monkeypox in humans in the Western Hemisphere. N Engl J Med 350:342–350. https://doi.org/10.1056/NEJMoa032299
📄 Chen S, Huang J, Chen J, Liu F, Wang S, Wang N, Li M, Zhang Z, Huang C, Du W, Liu L, Liu Z. 2025. Mpox virus: virology, molecular epidemiology, and global public health challenges. Front Microbiol 16:1624110. https://doi.org/10.3389/fmicb.2025.16...
📄 World Health Organization. 2025. Mpox: multi-country external situation report no. 53. WHO, Geneva, Switzerland. Published 29 May 2025. https://www.who.int/publications/m/it...
📄 O'Toole Á, Neher RA, Ndodo N, Borges V, Gannon B, Gomes JP, Groves N, King DJ, Maloney D, Lemey P, Lewandowski K, Loman N, Myers R, Omah IF, Suchard MA, Worobey M, Chand M, Ihekweazu C, Ulaeto D, Adetifa I, Rambaut A. 2023. APOBEC3 deaminase editing in mpox virus as evidence for sustained human transmission since at least 2016. Science 382:595–600. https://doi.org/10.1126/science.adg8116
📄 Chen Y, Li M, Fan H. 2022. The monkeypox outbreak in 2022: adaptive evolution associated with APOBEC3 may account for increased transmission. Signal Transduct Target Ther 7:323. https://doi.org/10.1038/s41392-022-01...
📄 Khan MI, Saleh AA, Ali R, Jan RU, Gu J, Dejun J. 2025. The evolving mpox threat (2022–2024): clade dynamics, immune evasion, and escalating global health challenges. Front Cell Infect Microbiol 15:1677762. https://doi.org/10.3389/fcimb.2025.16...
📄 Marty AM, Beÿ CK, Koenig KL. 2024. 2024 mpox outbreak: a rapidly evolving public health emergency of international concern: introduction of an updated mpox Identify-Isolate-Inform (3I) tool. One Health 19:100927. https://doi.org/10.1016/j.onehlt.2024...
📄 SIGA Technologies, Inc. 2024. Interim results from STOMP study of SIGA's tecovirimat in treatment of mpox announced. Press release. SIGA Technologies, New York, NY. Published 10 December 2024. https://www.siga.com
Alan Yoshiaki é Doutor em Química
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