Benefits & Risks of Peptide Therapeutics for Physical & Mental Health

In this episode, I explain the major categories and types of peptides currently in use for therapeutic purposes. I discuss peptides for improving tissue rejuvenation and repair, promoting longevity, improving muscle growth and fat loss, and boosting mood, vitality, and libido. I explain the biology of how these peptides work and both their potential benefits and risks. I also discuss peptide sourcing, dosages, cycling, routes of administration, and how peptides work in combination.

This episode will help you better understand the rapidly expanding landscape of peptide therapeutics and how to evaluate if specific peptides might be advantageous towards achieving your physical or mental health goals.

Use Ask Huberman Lab, our new AI-powered platform, for a summary, clips, and insights from this episode: https://ai.hubermanlab.com/s/NOL4NN0X

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Journal Articles
Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth: https://bit.ly/3TYHRoB
Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing: https://bit.ly/3xcwRLc
Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway: https://go.nature.com/43DYYz2
Stable Gastric Pentadecapeptide BPC 157 and Wound Healing: https://bit.ly/3J0sS77
Insulin-like growth factor 1 (IGF-1): a growth hormone: https://bit.ly/43WpDaN
MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism1: https://bit.ly/3PInRnA
Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure: https://bit.ly/3PJKrfB
Kisspeptin signalling and its roles in humans: https://bit.ly/4cBfMeh
Age-Related Changes of the Pineal Gland in Humans: A Digital Anatomo-Histological Morphometric Study on Autopsy Cases with Comparison to Predigital-Era Studies: https://bit.ly/3TGYzHv

Huberman Lab Episodes Mentioned
Dr. Natalie Crawford: Female Hormone Health, Fertility & Vitality: https://www.hubermanlab.com/episode/d...
Dr. Michael Eisenberg: Improving Male Sexual Health, Function & Fertility: https://www.hubermanlab.com/episode/d...
The Science of How to Optimize Testosterone & Estrogen: https://www.hubermanlab.com/episode/t...

Timestamps
00:00:00 Peptides
00:03:20 Sponsors: Mateína, Levels & Joovv
00:07:44 What is a Peptide?, Effects
00:12:06 Peptide Sourcing, Lipopolysaccharide (LPS)
00:14:48 Rejuvenation & Tissue Repair: BPC-157, Angiogenesis
00:21:50 BPC-157 & Tissue Injury; Mode of Delivery
00:27:53 BPC-157: Safety, Doses, Cycling, Tumor Risk
00:35:16 Sponsor: AG1
00:36:43 Tissue Repair: Thymosin Beta-4, TB-500
00:40:49 Growth & Metabolism: Growth Hormone, IGF-1, Risks
00:45:25 Secretagogues, Sermorelin, Tesamorelin, CJC-1295
00:52:21 Sponsor: LMNT
00:53:44 Ipamorelin, Hexarelin, GHRP-3, MK-677; Risks & Timing
00:58:69 Peptides for Growth Hormone & IGF-1, Risk; Combinations & Dosing
01:06:12 Longevity: Thymosin Beta-4, Epitalon (Epithalon)
01:12:09 Vitality: Melanotan, PT-141 (Vyleesi), Risks
01:17:21 Vitality: Kisspeptin
01:21:46 Peptides, Potential Benefits, Side-Effects & Risks
01:24:19 Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter

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Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com

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