Mitochondria aren’t just the “powerhouses of the cell”—they are central to brain function, mental health, and psychiatric disorders. In this video, Dr Sanil Rege (Consultant Psychiatrist and Founder of The Academy by Psych Scene
) explains how mitochondrial dysfunction affects mood, cognition, and resilience, and explores practical ways to enhance mitochondrial health.
⏱️ Chapters
00:00 – Introduction: Why mitochondria matter for mental health
00:15 – Mitochondria as the brain’s power plants
02:49 – Energy production & psychiatric symptoms (ATP, fatigue, cognitive slowing)
03:17 – Neurotransmitter regulation: serotonin, dopamine & stress responses
07:05 – Oxidative stress, ROS, and neurodegeneration
09:00 – Calcium regulation, excitotoxicity & synaptic plasticity
05:26 – Linking mitochondrial dysfunction to depression, bipolar disorder, schizophrenia & neurodegeneration
05:42 – How psychiatric treatments like lithium impact mitochondrial health
06:12 – Modifiable strategies: exercise, diet, supplements, and stress management
🚀 4 Ways to Supercharge Your Mitochondria
1. Exercise – boosts mitochondrial biogenesis and metabolic resilience.
2. Dietary strategies – ketogenic diets, intermittent fasting, and nutrients like CoQ10, omega-3s, and B vitamins.
3. Medications & supplements – lithium, creatine, acetyl-L-carnitine, and antioxidants such as NAC.
4. Stress & sleep optimisation – reducing chronic stress and prioritising restorative sleep to repair mitochondria.
Clinical Relevance: Helps clinicians refine treatment strategies and provides patients and biohackers with actionable ways to improve brain energy and resilience.
🔑 Key Takeaways
Mitochondria & Mental Health: Dysfunction can drive depression, bipolar disorder, schizophrenia, and neurodegeneration.
Energy Deficits: Reduced ATP is linked to fatigue, anhedonia, and slowed cognition.
Neurotransmitters & Inflammation: Mitochondria regulate serotonin, dopamine, glutamate, and the inflammatory response.
Oxidative Stress & Calcium: Disrupted balance accelerates neurodegeneration and impairs resilience.
👨⚕️ About Dr Sanil Rege
Dr Sanil Rege is a Consultant Psychiatrist, educator, and Founder of The Academy by Psych Scene, an advanced CPD platform for mental health professionals. His work integrates neuroscience, psychopharmacology, and clinical psychiatry into practical, cutting-edge education.
👉 Learn more at The Academy by Psych Scene
#Mitochondria #MentalHealth #Psychiatry #MetabolicPsychiatry #BrainEnergy #Depression #BipolarDisorder #Schizophrenia #Neurobiology #PsychScenen
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