Скачать или смотреть Triptans

CLASS: Triptans
Drug Class: Selective 5-HT₁B/₁D receptor agonists
Derived From: 5-Hydroxytryptamine (Serotonin)
Purpose: Abortive treatment for migraines and cluster headaches
Examples: Sumatriptan, Rizatriptan, Zolmitriptan

🧠 MECHANISM OF ACTION
Triptans relieve migraines by acting on serotonin receptors in the brain:
Vasoconstriction
Stimulate 5-HT₁B receptors on cranial blood vessels
Reverse migraine-associated vasodilation
Neurotransmitter Inhibition
Activate 5-HT₁D receptors on trigeminal nerve endings
Suppress release of CGRP, substance P, and neurokinin A
Pain Signal Modulation
Reduce transmission of pain signals in the brainstem

💊 USES
Acute Migraine Attacks
Cluster Headaches
Menstrual Migraine Relief

⚠️ SIDE EFFECTS
Chest Pressure or Tightness
Dizziness or Fatigue
Tingling or Numbness (Paresthesia)

🚫 CONTRAINDICATIONS
Avoid Triptans in patients with:
Coronary Artery Disease or history of heart attack
Uncontrolled Hypertension
Stroke or Transient Ischemic Attack (TIA)
#viralvideos #medicine
#medicalstudent
#pharmacology
#pharmacist