Platelet Plug Formation is SO AMAZING

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Video Summary:
Platelet plug formation is also called Primary Hemostasis. There are three main steps in Platelet plug formation. Platelet adhesion, platelet activation and platelet aggregation. Platelet adhesion is initial covering of wound area by platelets. It starts with release of von Willebrand factor by damaged endothelial cells. They bind to the collagen that is exposed as result of vessel injury. Platelet adhesion is mediated by platelet receptor glycoprotein Ib (Gp Ib) which bind with Von Willebrand factor and glycoprotein Ia/IIa and glycoprotein VI both of which bind with collagen. This binding causes platelet activation and activated platelet releases ADP, fibrinogen and some other important factors from their α and dense granules. They freshly synthesize and release thromboxane-A2. Also, thrombin is generated on platelet surface due to simultaneous activation of coagulation cascade. Platelet changes shape to increase the surface area for binding with more platelets. Finally, glycoprotein IIb/IIIa undergo conformational change and bind with fibrinogen. This is followed by next step, platelet aggregation. ADP, TxA2 and thrombin activate more circulating platelets by acting on P2Y12, TP and PAR-1 respectively. Platelets, activated thus, release more ADP, TxA2 and thrombin to activate even more platelets and meanwhile also bind with other activated platelets with help of Gp IIb/IIIa/. Here fibrinogen and Von Willebrand factor serve as bridge to connect platelets. In this way platelets are recruited till the break in vessel is plugged. This initial plug is called primary platelet plug or primary haemostatic plug. It is stabilized with help of fibrin that is generated at the end of parallelly occurring coagulation cascade.

● Hemostasis Physiology:
• Blood Coagulation Cascade:    • You Will FALL IN LOVE WITH PHYSIOLOGY...  
• Clot Retraction & Fibrinolysis:    • Clot Retraction & Fibrinolysis  

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Chapters
00:00 Intro
00:12 Damage to the Blood Vessel
00:45 Platelet Adhesion
01:20 Platelet Activation and Release Reaction
03:01 Platelet Aggregation
04:41 Summary

#NonstopHemostasis

Dr Vipul Navadiya

DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.