Скачать или смотреть The Role of Mast Cells in Complex Illness What They Are and How to Calm Them

Dr. Theoharis Theoharides, Professor and Vice Chair of Clinical Immunology and Director at the Institute for Neuro-Immune Medicine-Clearwater, explores the role of mast cells in complex chronic illness on the Make Visible Podcast.

He unpacks how mast cells can become overly reactive after infections, trauma, or stress. Instead of focusing only on histamine, Dr. Theoharides explains why we need to look at the full picture.

He shares how mast cell activation might be involved in conditions like ME/CFS, fibromyalgia, POTS, migraines, and long COVID, and why most doctors are still missing it.

If you've ever felt dismissed or stuck searching for answers, this episode offers clarity, hope, and a science-backed perspective on what might really be going on in your body.

Key Points:
00:00 Introduction
03:50 Confusion around allergies, mast cell activation, and related conditions.
04:47 How mast cells are present throughout the body.
07:54 Mast cells reacting to physical and emotional stress.
08:51 Do mast cells build up gradually or from one major trigger?
09:46 The role of inhibitors in the body.
13:04 Molecules released by mast cells and their effects.
15:44 Why diagnosing MCAS is so challenging.
20:45 Mast cells’ involvement in migraines, ME/CFS, and more.
21:49 Are mast cells activated in specific areas like the gut or brain?
24:58 Mast cells open the blood-brain barrier and cause neuroinflammation.
28:56 Common symptoms of mast cell activation.
30:11 Why antihistamines don’t always help.
34:24 Flavonoids as natural mast cell inhibitors.
39:09 Tetramethoxyluteolin for mast cell–related skin conditions.
45:05 Why funding and research for mast cells is limited.
49:51 Lack of holistic, cross-disciplinary research on mast cells.
55:29 The future of mast cell research at NSU.
55:29 Example of a new clinical trial targeting long COVID.


Dr. Theoharis C. Theoharides is a leading expert in mast cells and neuroinflammation, with over 40 years of research experience. He serves as Executive Director of the Center of Excellence for Neuroinflammation Research at Nova Southeastern University and was previously Professor at Tufts University. His groundbreaking work on mast cells, stress, and chronic illness has led to over 490 publications and 30 patents, earning him global recognition as one of the top experts in his field.

Website: https://www.drtheoharides.com/
LinkedIn:   / nancy-klimas-49255178  

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