Journal of Clinical Investigation

The Journal of Clinical Investigation is a premier venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine.

Pathways for monovalent and divalent cation transport and distinct cell types
Pathways for monovalent and divalent cation transport and distinct cell types
Breast cancer immunotherapy is enhanced by the gut microbiome following bariatric surgery
Breast cancer immunotherapy is enhanced by the gut microbiome following bariatric surgery
Bone growth promotion in two FGFR3-driven models of chondrodysplasia
Bone growth promotion in two FGFR3-driven models of chondrodysplasia
Response to immunotherapy in metastatic urothelial cancer and multimodal integration of blood
Response to immunotherapy in metastatic urothelial cancer and multimodal integration of blood
MD-PhD program admissions: application metrics and predicting outcomes
MD-PhD program admissions: application metrics and predicting outcomes
JCI’s Conversations with Giants in Medicine: Ending one conversation
JCI’s Conversations with Giants in Medicine: Ending one conversation
Baricitinib rapidly treats lichen planus by suppressing cytotoxic CXCL13+CD8+ T cells
Baricitinib rapidly treats lichen planus by suppressing cytotoxic CXCL13+CD8+ T cells
Brain toxicity via kidney injury is potentially linked by quinolinic acid
Brain toxicity via kidney injury is potentially linked by quinolinic acid
Electronic health record data and the estimation of autoimmune disease prevalence in the USA
Electronic health record data and the estimation of autoimmune disease prevalence in the USA
Gut inflammation in mice is alleviated by glucose-dependent insulinotropic polypeptide receptor
Gut inflammation in mice is alleviated by glucose-dependent insulinotropic polypeptide receptor
JCI’s Conversations with Giants in Medicine: Zhijian (James) Chen
JCI’s Conversations with Giants in Medicine: Zhijian (James) Chen
Chronic lymphocytic leukemia and the inducement of a nongenetic adaptation to ibrutinib
Chronic lymphocytic leukemia and the inducement of a nongenetic adaptation to ibrutinib
Macrophage subtypes mediate the development of the ordered architecture of regenerative tissues
Macrophage subtypes mediate the development of the ordered architecture of regenerative tissues
The Women’s Health Initiative and lung cancer in never-smokers
The Women’s Health Initiative and lung cancer in never-smokers
Conversations with JCI Editors in Chief: Question 3
Conversations with JCI Editors in Chief: Question 3
Conversations with JCI Editors in Chief: Question 2
Conversations with JCI Editors in Chief: Question 2
Conversations with JCI Editors in Chief: Question 1
Conversations with JCI Editors in Chief: Question 1
Happy Birthday JCI!
Happy Birthday JCI!
A dynamic multilayered tissue architecture is revealed in skeletal muscle
A dynamic multilayered tissue architecture is revealed in skeletal muscle
JCI’s Conversations with Giants in Medicine: JCI Editors in Chief
JCI’s Conversations with Giants in Medicine: JCI Editors in Chief
Preserving kidney function with aldehyde dehydrogenase 2
Preserving kidney function with aldehyde dehydrogenase 2
Remodeling abnormalities in mitochondrial trifunctional protein deficiency
Remodeling abnormalities in mitochondrial trifunctional protein deficiency
ADAMTS12 promotes fibrosis and enables activation of injury-responsive fibroblasts
ADAMTS12 promotes fibrosis and enables activation of injury-responsive fibroblasts
Murine lupus protection and regulation of TLR7
Murine lupus protection and regulation of TLR7
Sex- and age-specific differences revealed by mouse sarcopenia models
Sex- and age-specific differences revealed by mouse sarcopenia models
Folate treatment for lethal arrhythmias in TANGO2-deficiency disorder
Folate treatment for lethal arrhythmias in TANGO2-deficiency disorder
Tet2 function and innate immune resistance to bacterial pneumonia
Tet2 function and innate immune resistance to bacterial pneumonia
JCI’s Conversations with Giants in Medicine: Stanley Prusiner
JCI’s Conversations with Giants in Medicine: Stanley Prusiner
Immune responses to 4CMenB vaccine exhibited in children with perinatally acquired HIV
Immune responses to 4CMenB vaccine exhibited in children with perinatally acquired HIV
Prolonged transplant survival in preclinical models
Prolonged transplant survival in preclinical models