What is Gout? - Pathology mini tutorial

Gout is caused by a high level of uric acid in the bloodstream. It affects males more frequently than females first presenting from the age of around 20.
0:00 Intro
0:10 Crystal arthropathy, origin of the word gout, gout and synovial fluid supersaturated with sodium urate
1:26 Sodium urate crystals from synovial fluid aspirate
1:44 Causes of primary gout including genetic predisposition, obesity, diabetes, hypertension, diet rich in purines eg red meat and shellfish. X-linked Lesch-Nyhan syndrome is also a risk factor due to deficiency of HGPRT enzyme (guanine phosphoribosyl transferase)
2:24 Causes of secondary gout include leukaemias, myeloproliferative disorders and destruction of tumour cells by chemotherapy, thiazide diuretics, low dose aspirin and lead poisoning
2:43 How gout develops from tissue breakdown to eventual tophus formation
3:24 Sites commonly affected by gout include metatarsophalangeal joint of big toe at the ball of the foot, bursae, tendons, ear - especially the pinna
4:00 Symptoms of acute and chronic gout
4:24 Gross and microscopic appearance of gout description
4:52 Images of gout with multinucleated foreign body giant cells
5:27 Sodium urate crystals before and after polarisation
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