Metabolism of Bilirubin - Dr Mahesh

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Metabolism of Bilirubin - Dr. Mahesh

Unconjugated bilirubin (insoluble in water) is released into the blood by macrophages → binds to albumin and reaches the liver
Unconjugated bilirubin is converted into bilirubin via the enzyme UDP-glucuronosyltransferase in the liver.
Bilirubin is conjugated with glucuronic acid → bilirubin diglucuronide = conjugated bilirubin (water-soluble)
Most conjugated bilirubin is excreted into the GI tract via bile, while some is released into the blood.
Conjugated bilirubin excreted in bile is broken down by GI bacteria into urobilinogen
Most urobilinogen is converted to stercobilin → excreted in feces (brown color).
Part of urobilinogen oxidates to urobilin → excreted in the urine (yellow color).

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