Скачать или смотреть Organ Specific Autoimmune disorders

Dr Neha Kapoor
School of Applied Sciences, Suresh Gyan Vihar University, Jaipur, Rajasthan
https://www.gyanvihar.org/school/appl...

Autoimmunity, Immune response, Self-antigen, T cell, Antibodies, Immunology, Lecture Notes, Biotechnology

The topic is aimed at imparting an understanding of various autoimmune disorders based on their localization, mechanism of action of autoreactive lymphocytes, and autoantibodies for the progression of the autoimmune state.

Autoimmunity is the failure of the immune system in which an organism’s immune response is generated towards its own constituent parts as nonself. This autoimmune state results in the breakdown of the mechanisms normally responsible for maintaining self-tolerance in B cells, T cells, or both. Organ-specific autoimmune diseases include the specific cell or tissue targeting by the patient’s immune system. Therefore, the clinical presentation of the disease depends on where it occurs. As a result, the diagnosis and management of autoimmune diseases have been discrete among different clinical conditions. The similarity among different autoimmune diseases despite the differences in tissue specificity includes the chance resemblance of a number of genetic traits, which, in the aggregate, increase the risk of developing an autoimmune disease. The most prominent traits are located in the MHC, however the majority of the other genes are involved in regulation. The lecture narrates the detailed insight on the pathogenesis of organ-specific autoimmune disorders taking multiple examples.