What are Autoimmune Diseases and How Do They Develop?

What are Autoimmune Diseases? Autoimmune Diseases are caused when the immune system attacks its own cells. This video is about autoimmunity, how autoimmune diseases develop, and the symptoms they cause. Find out how autoimmune antibodies, B-cells and T-cells get made and how they get activated. Autoimmune cells are activated via molecular mimicry, bystander activation and epitope spreading. Persistent infections can increase the stimulation of the immune system over a person's lifetime and increase the chances of activating autoimmune cells.

Autoimmune Diseases can affect one organ, as in Type I Diabetes or many organs, as in Lupus. More than 100 autoimmune disorders affect 5-10% of people worldwide.

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CHAPTERS:
00:00 What is an Autoimmune Disease?
00:13 Types of Autoimmune Disease
00:38 Autoimmune Disease Risk
00:59 Autoimmune Disease Symptoms
01:15 Autoimmune Disease Diagnosis
01:27 Autoantibodies
01:53 Autoimmunity and Immune Tolerance
02:27 Role of Antibodies
02:33 B-Cell Development
03:14 T-cell Development
04:04 Activation of Autoreactive B & T-Cells
04:10 Molecular Mimicry
04:35 Bystander Activation
05:11 Epitope Spread
06:40 Viral Persistence
06:59 Symptoms Depend on Target Antigen
07:79 Autoimmune Disease Treatment

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