Total Synthesis of Lysergic Acid (LSD Precursor): Retrosynthesis & Mechanisms (Hofmann, Woodward)

Welcome to this channel on organic synthesis. This is not an experimental channel showcasing chemical experiments but rather will deal with theoretical discussions of syntheses of important chemicals and interesting natural products. If you are not familiar with organic chemistry, do not expect to understand everything I'm talking about. Please consult the literature, the myriad of youtube videos about basic chemistry or just Google.

In this first video, we will cover the history of lysergic acid, a LSD precursor, its first total synthesis and a modern approach (with increasing difficulty).

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00:00 Introduction about the significance of lysergic acid derivatives and importance of natural products
00:49 Overview
02:09 History preceding the synthesis of lysergic acid about the work of Albert Hofmann at Sandoz (first semisynthesis)
04:12 First total synthesis by chemists at Lilly & Nobel laureate Robert Burns Woodward. This synthesis employs reactions encountered at in the first two years at an undergrad level.
12:40 Modern approach by Prof. Ohno at Kyoto University. This contemporary synthesis relies on organometallic chemistry and more advanced retrosynthetic disconnections. This part contains a short discussion of reaction mechanism.
18:10 Closing comments

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No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube.

Some recommended books on organic synthesis:
- Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge)
- Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis)
- Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions)
- Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy)
- Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
- Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)