Can someone with an APOE4 genotype follow a ketogenic diet? | Dominic D'Agostino

The ketogenic diet is contraindicated in people with pancreatitis, fat metabolism disorders, and other rare metabolic conditions. Some people carry a version of the apolipoprotein E gene called APOE4 – a risk factor for late-onset Alzheimer's disease. This gene variant affects fat metabolism and distribution to the brain. Dr. D'Agostino questions whether a high-fat ketogenic diet is suitable for people carrying an APOE4 gene variant. He suggests it may be prudent to select a more liberalized version of the diet and gradually restrict carbohydrates and monitor biomarkers for adverse reactions. Other thoughts include incorporating fiber-rich vegetables and choosing unsaturated rather than saturated fats. In this clip, Dr. Dominic D'Agostino discusses the applicability of a ketogenic diet for people with an APOE4 gene variant.

Interview published on April 28, 2022

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#Ketogenic #Diet #Metabolism