Alpha-Synuclein's Role in Parkinson's and Mitochondrial Dynamics - Dr. David Eliezer

This week at Journal Club, Dr. David Eliezer, Professor at Cornell Medicine presents his recent publication "Alpha synuclein modulates mitochondrial Ca2+uptake from ER during cell stimulation and under stress conditions" published in NPJ Parkinson's Disease on 23 September, 2023. The study investigates how alpha-synuclein affects calcium flux between the ER and mitochondria and its potential role in the pathology of Parkinson's disease.

Link to full article:
https://www.nature.com/articles/s4153...

#journalclub #research #science #mitochondria #biology #cornell #openscience #vincere #parkinsons #synuclein

Dr. Eliezer's Profile and Social Media:
Profile: https://biochem.weill.cornell.edu/dir...
LinkedIn:   / david-eliezer-b930191  

Chapters:

00:00-00:56 Introduction
00:57-03:30 Background
03:31-07:32 Results - Alpha-synuclein can inhibit/enhance vesicle exocytosis and bridge between membranes
07:33-10:11 Results - Independent binding by helix-1 and helix-2 and mutations of Val 70 in helix-2 (V70P)
10:12-12:55 Results - Alpha-synuclein partially colocalizes with mitochondria
12:56-15:17 Results - Mitochondrial relocalization is prevented by mutations
15:18-17:19 Results - Alpha-synuclein localization to ER-mitochondrial contact sites
17:20-20:18 Results - Alpha-synuclein enhances stimulated calcium uptake by mitochondria
20:19-21:52 Results - Recovery from mitochondrial toxin stress results in enhanced stimulated calcium uptake
21:53-21:58 Results - Alpha-synuclein relocates to mitochondria under mitochondrial/cell stress
21:59-24:13 Results - Alpha-synuclein inhibits recovery from mitochondrial toxin stress
24:14-25:40 Results - Alpha-synuclein Ser129 phosphorylation increases after recovery from toxin treatment
25:41-26:58 Alpha-synuclein relocation to mitochondria stress under mitochondrial/cell stress eliminates recovery of calcium entry
26:59-28:08 Summary and Conclusion
28:09-50:42 Q&A