ASCP | MLS | MLT | Hematology | Introduction to Increased Destruction of Erythrocytes

👉ASCP Short Notes in Hematology: https://www.amazon.com/dp/B0CYK4QV9P
In this video, we delve into the complex world of hemolysis, a process in which red blood cells are destroyed. We start by defining hemolysis and its hallmark clinical findings. Then, we differentiate between hemolytic disorder and hemolytic anemia based on laboratory findings. We also discuss methods of classifying hemolytic anemias and apply this classification to an unfamiliar anemia. We describe the two processes of hemolysis, fragmentation (intravascular) and macrophage-mediated (extravascular), including sites of hemolysis, catabolic products, and the time frame for their appearance. Additionally, we explain protoporphyrin catabolism and the metabolites and sites of production and excretion. We also describe the mechanisms that salvage hemoglobin and heme during fragmentation hemolysis. Finally, we identify and interpret laboratory tests that indicate increased hemolysis and erythropoiesis and differentiate between hemolytic anemias and other causes of increased erythropoiesis and bilirubinemia. Don't miss out on this comprehensive guide to understanding hemolysis!