Is the Serotonin Theory of Depression DEBUNKED?

The serotonin hypothesis (or in popular terms, serotonin theory) has been an influential idea since the discovery of the first antidepressant drugs in the 1950s. A recent review article has supposedly debunked the idea that serotonin has anything to do with depression. In this video, I will give my pharmacologists perspective on the topic.

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Additional reading:

The serotonin theory of depression: a systematic umbrella review of the evidence
PMID: 35854107 DOI: 10.1038/s41380-022-01661-0

Expert reaction to a review paper on the ‘serotonin theory of depression’
https://www.sciencemediacentre.org/ex...

Background on antidepressant research
https://helda.helsinki.fi/handle/1013...