Psychedelics Promote Brain Plasticity by Binding to TrkB receptors

Two years ago, I pondered the possibility of psilocybin binding directly to TrkB receptors - and it seems like the future is here. This recent study, "Psychedelics promote plasticity by directly binding to BDNF receptor TrkB", published in the renowned Nature Neuroscience journal, substantiates this hypothesis.

In this video, I will explore the study's controversial findings regarding how psychedelics like psilocybin may enhance neuroplasticity - the brain's ability to form and reorganize synaptic connections.

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Further reading:

Moliner, R., Girych, M., Brunello, C.A. et al. Psychedelics promote plasticity by directly binding to BDNF receptor TrkB. Nat Neurosci 26, 1032–1041 (2023). https://doi.org/10.1038/s41593-023-01...

Maxemiliano V. Vargas et al. Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science 379,700-706(2023). DOI: 10.1126/science.adf0435

Nardou, R., Sawyer, E., Song, Y.J. et al. Psychedelics reopen the social reward learning critical period. Nature 618, 790–798 (2023). https://doi.org/10.1038/s41586-023-06...

Referenced videos:

   • Three Hypotheses of Psychedelic Action  
   • Psilocybin and 5HT2A receptors - Are ...