Dose Number as a Tool to Guide Lead Optimization of Orally Bioavailable Compounds

In general, more soluble compounds have improved oral absorption. While enabling formulation technologies exist to improve bioperformance for low solubility compounds, these are often more complex, expensive, and challenging to scale up.

In this Flask Talk, Peter Wuelfing and Abdellatif ElMarrouni presented a tool to avoid these development issues. Medicinal chemists need tools to rapidly profile and improve the physicochemical properties of molecules during discovery. Dose number (Do) is a simplified metric to predict whether a compound will be reasonably absorbed based on solubility at an expected clinical dose and represents a valuable parameter to the medicinal chemist defining a clinical candidate.

00:00 Welcome and introduction
10:44 Overview of Drug Hunter feature: Searchable INN list
12:19 Presentation
49:32 Q&A

The slide deck from this Flash Talk will be available for Drug Hunter Premium subscribers to access and download here:

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Presented by Abdellatif El Marrouni, Ph.D. and Peter Wuelfing, Ph.D. with host Dennis Koester, Ph.D. Director of Industry Research and Relations, Drug Hunter

Recorded on October 10, 2024, as a Drug Hunter Flash Talk.

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