Drugs That Modulate Cerebrospinal Fluid (CSF) Production

0:00 Introduction
0:13 CSF formation
2:40 Carbonic anhydrase inhibitors
6:52 Acetazolamide
9:40 Topiramate
12:56 Furosemide
14:28 Omeprazole
18:52 Cimetidine and Famotidine
20:38 Corticosteroids (prednisolone, dexamethasone)
22:08 Aquaporins
24:31 Emergency / short term management hydrocephalus
25:50 Medical management chronic hydrocephalus
26:52 Drugs to reduce syrinx filling?
In this episode, we unravel the complexities of cerebrospinal fluid (CSF) production by the choroid plexus cells and discuss the neuropharmacology of agents that influence production.
💊 We discuss the mechanisms of carbonic anhydrase inhibitors like acetazolamide, topiramate, and furosemide, exploring how these drugs can influence CSF production.
🔬 Take a closer look at lesser-known players in CSF modulation, such as cimetidine and omeprazole. Understand the science behind these drugs and whether they have a role in management of cerebrospinal fluid disorders.
🌐 We'll also explore the use of corticosteroids in the context of CSF regulation, shedding light on their mechanisms and applications in managing conditions like acute hydrocephalus
👁️‍🗨️ Dive into the discussion on aquaporins and their potential as future targets for neuropharmacological manipulation of cerebrospinal fluid. Discover the evolving landscape of research and possibilities in this dynamic field.
🤔 Lastly we discuss what drugs are most useful and least useful for emergency and short term management of acute hydrocephalus; chronic hydrocephalus and syringomyelia.
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