Mantle Cell Lymphoma - Aggressive B-Cell Neoplasm - Non-Hodgkin’s Lymphoma (NHL) - Hematology

Mantle Cell Lymphoma - Aggressive B-Cell Neoplasm - Non-Hodgkin’s Lymphoma (NHL) - Hematology




Hematological malignancies can be divided into leukemias, lymphomas, and multiple myeloma.

Lymphomas can be divided into Hodgkin's lymphoma and non-Hodgkin's lymphoma.

Non-Hodgkin's lymphoma can be subdivided into aggressive lymphoma and indolent lymphoma.

Aggressive non-Hodgkin's lymphoma includes:
*Diffuse large B-cell lymphoma​ (DLBCL)
*Burkitt's lymphoma.
*Mantle cell lymphoma.
*Precursor T-cell lymphoblastic lymphoma.
*B-lymphoblastic lymphoma.


Indolent non-Hodgkin's lymphomas include:
*Follicular lymphoma
*Marginal zone B-cell lymphoma (MALToma)
*Hairy cell leukemia/ lymphoma.
*Waldenstrom macroglobulinemia.
*Mycosis fungoides/ Sezary syndrome.

Mantle cell lymphoma is a rare, aggressive B-cell non-Hodgkin's lymphoma that affects people around 63 years of age...More common in females than males...t(11;14) translocation is common. Overexpression of BCL-1 "cyclin D1" leads to increased proliferation of cancer cells.

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