What Are Atypical Parkinsonisms?

Atypical Parkinsonisms present with some of the signs and symptoms of Parkinson’s disease, but generally do not respond well to drug treatment with levodopa.

Yvette Bordelon received her MD and PhD degrees from the University of Pennsylvania. Her thesis work was performed with Dr. Marie-Francoise Chesselet and focused on understanding the brain circuitry involved in movement and mood and thinking.

She went on to residency training at Massachusetts General and Brigham and Women’s Hospitals and then did a Movement Disorders Fellowship at Columbia University.

Dr. Bordelon specializes in atypical variants of Parkinson’s disease, and in 2024 joined the Movement Disorders Program in the Department of Neurology at Cedars Sinai.

A Parkinson's Community Los Angeles (PCLA) "Let's Talk Parkinson's" online live program from July 12, 2024. www.pcla.org.
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Timestamps:
00:00 Intro
01:09 Speaker Intro
03:00 Outline
03:15 Overview of Atypical Parkinsonisms
03:46 Diagnosis
04:50 Parkinsonisms plus…
06:43 Diagnosis continued
08:54 Is an exact diagnosis necessary to guide treatment?
09:48 Classified by Pathologic Cause
11:29 Location of protein tangles - relates to symptoms
13:07 TAU Disorders
13:19 Progressive Supranuclear Palsy (PSP)
20:27 Corticobasal Degeneration/Syndrome (CBD/S)
23:40 Synuclein Disorders
23:48 Multiple System Atrophy (MSA)
27:31 Dementia with Lewy Bodies (DLB)
30:39 Other Parkinsonisms
31:12 Summary of Parkinsonism Diagnosis
34:48 Atypical Parkinsonism Treatment
40:18 Why exercise?
40:56 Research pipeline: treatments under development
41:15 Tauopathies
41:53 PSP Clinical Trial: Enrolling
42:48 Synucleinopathies
44:11 Trial for all atypical Parkinsonisms
46:52 Multi-Disciplinary Holistic Care
47:54 Summary
49:09 Q&A
56:52 Closing
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🎥 Related Content:
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