Cannabinoids Explained In Detail

What are cannabinoids? Why are cannabinoids important?

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Many people are trying to appreciate cannabis’ anti inflammatory benefits as it slowly acquires legal status worldwide. After all, mental disorders, chronic pain, and even numerous chronic illnesses are all on the list of conditions for cannabis use.

Potentially hundreds of specialized cannabinoids in the cannabis plant have been found to provide therapeutic efficacy, lifestyle enhancement, and even performance improvement to humans. Medical cannabis has been discovered to have a wide range of health benefits for persons suffering from sickness, including eliminating malignant tumors, anxiety and depression, relieving arthritis pain through anti inflammatory effects, and reducing the number of seizures experienced by epileptic children.

This list of cannabinoids contains the most well-known and studied of these compounds. Tetrahydrocannabinol (THC) is the most well-known cannabinoid, and it’s the chemical responsible for much of cannabis’ psychoactive (psychotropic) and euphoric effects, as well as being used to treat serious diseases like PTSD and cancer. Cannabidiol (CBD), a generally non-psychoactive compound that has been proven to give a wide range of medical advantages, including pain relief, anxiety relief, and depression relief, is another noteworthy cannabinoid.

Like THC, CBD offers therapeutic benefits – but without the high. All of these benefits are thanks to the endocannabinoid system.

The Endocannabinoid System

Because the ECS is found in all mammals, companies and product lines specialized in the health and well-being of domestic pets are starting to appear in legal cannabis marketplaces. Many cannabinoids in cannabis are important to identify, because medical studies show they might improve illnesses like arthritis, digestive difficulties, anxiety, and discomfort.

CB1 and CB2 Receptors

Internally produced cannabinoids (called endocannabinoids) and phytocannabinoids interact with the Endocannabinoid System through specialized cellular receptors (largely in the nervous system) known as CB1 and CB2 receptors, discovered in the 1990s. CB1 receptors are situated in the brain and central nervous system. In contrast, CB2 receptors are found in the immune system’s organs and tissues, such as the thymus, skin, lymph nodes, bone marrow, spleen, colon, and mucous membranes of the genitals, nose, bladder, and throat. Both can utilize cannabinoids in one way or another.

Where Are These Cannabinoids Found?

Before we go any further, it’s important to distinguish something: cannabinoids in cannabis are known as ‘phytocannabinoids.’ Cannabinoids produced by the human body are known as ‘endocannabinoids.’ The endocannabinoid system can utilize both cannabinoids, and phytocannabinoids.

Cannabinoids can be found in practically every part of the cannabis plant; however, the flowers contain the most. Cannabinoids are abundant on trichomes, which are hair-like structures on cannabis plant flowers. Cannabinoids were formerly thought to be only found in the cannabis plant, but studies have discovered that they may also be found in carrots, broccoli, ginseng, echinacea, and black pepper. That said, the cannabis plant is still regarded as the richest source of cannabinoids.

How are Cannabinoids Used?

We briefly covered the endocannabinoid system, but not how the cannabinoids are actually used in the human body. The cannabis plant contains well over 124 known cannabinoids, but what does this have to do with cannabis’ medical properties? I’m glad you asked!

Phytocannabinoids, or cannabinoids derived from cannabis, are structurally identical to endogenous cannabinoids made by the body. They can mimic endocannabinoids and bind to specific endocannabinoid receptors to change how the human body sends or receives messages using the central nervous and immune systems.

In the body, different cannabinoids have distinct effects. Tetrahydrocannabinolic acid, for example, is known to have a high propensity for CB1 receptors, which are the brain’s endocannabinoid receptors. Tetrahydrocannabinolic acid binds to CB1 receptors in the brain rapidly, resulting in the intoxicating effects that we’ve come to expect from high-THC cannabinoids. This is why THC is a psychoactive cannabinoid.

CBD (cannabidiol) is thought to interact differently with endocannabinoid receptors. According to researchers, it may bind indirectly, affecting the ability of the endocannabinoid receptor to bind with other cannabinoids. In other words, CBD may prevent specific neurotransmitters from reaching the brain, such as those that transmit pain.

Read more on the list of cannabinoids page...