Temperature Regulates Neurotrophic TrkB Signaling

In today's video, we dive deep into the surprising link between core body (brain) temperature and TrkB phosphorylation. 🌡️🔬 Despite the kind of treatment – anesthetics, antidepressants, antipsychotics, or even deep sleep – a decrease in body temperature always seems to elevate TrkB phosphorylation. But does that necessarily imply these treatments promote plasticity or exhibit antidepressant effects?

Key takeaways from our research:

The overlooked aspect: The widespread use of drugs like fluoxetine in high doses in preclinical research has often ignored the drug's potential impact on body temperature.

Rethinking previous literature: Considering the influence of even minor body temperature changes on TrkB signaling, past studies may have mistakenly attributed drug effects to what might actually be hypothermia-driven changes.

External factors: Rodent body temperature can be affected by various externalities like ambient housing temperature, group sizes, and more, potentially adding biases to molecular studies.

As we tread on this newfound path, we must acknowledge that while the functional role of these phosphorylation events remains a mystery, the possibility of its significance in the human brain is tantalizing. Time to dive back into the research and unravel this mystery further! If you found this topic as intriguing as I do, consider supporting our research!

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#TrkBPhosphorylation #BodyTemperature #NeuroscienceResearch

Original study:

Linking Hypothermia and Altered Metabolism with TrkB Activation
https://doi.org/10.1021/acschemneuro....