Physiology of the Lymphatic System - Timothy Padera, PhD - Harvard Symposium 2018

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Physiology of the Lymphatic System - Timothy Padera, PhD - Harvard Symposium 2018

Dr. Padera earned dual Bachelor’s Degrees in Chemical Engineering and Biomedical Engineering from Northwestern University. He earned his PhD in Medical Engineering from the Harvard-MIT Health Sciences and Technology program. He performed his thesis work in the laboratory of Dr. Rakesh Jain at Massachusetts General Hospital. He was appointed to the faculty of Harvard Medical School as an Instructor and has risen through the ranks and is now Associate Professor of Radiation Oncology at Harvard Medical School and a PI in the Edwin L. Steele Laboratories, Department of Radiation Oncology at Massachusetts General Hospital. In 2011, he was awarded an NIH Director’s New Innovator Award.

Dr. Padera is recognized as a leader in the field of functional lymphatic imaging, particularly with respect to tumor growth and lymphatic metastasis. He has seminal papers describing the role of functional peritumor lymphatic vessels in tumor dissemination and the source of lymphatic dysfunction in tumors. His group has also developed a novel method to study the autonomous contraction of collecting lymphatic vessels in mice. This work opened the door to the wide array of genetic mouse models to study underlying functional lymphatic deficits in lymphedema, states of inflammation and bacterial infection. Most recently, his group has developed the first chronic lymph node window in a mouse. Using this novel model, his lab has shown that lymph node metastases do not require sprouting angiogenesis for their growth and do not respond to anti-angiogenic therapy. Further, they have shown the lymph node metastasis can spread to distant organs by invading lymph node blood vessels, contributing to the progression of cancer.

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